Xin Huang, PhD

Assistant Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, Division of Gynecological Oncology, University of Pittsburgh

Research

Description

The main goals of the Huang laboratory are to: (1) Understand the role of tumor hypoxia in ovarian cancer initiation and progression, especially the function of the hypoxia-inducible microRNA, miR-210, during this process. (2) Identify genes critical for ovarian cancer transcoelomic metastasis. (3) Identify biomarkers for ovarian cancer early detection and prognosis.

For more information, see http://www.pitt.edu/~xih20

 

Selected Publications

  • Ho AS*, Huang X*, Cao H, Christman-Skieller C, Le QT, & Koong AC. Circulating miR-210
    as a novel hypoxia marker in pancreatic cancer. Translational Oncology, 2010; 3(2): 109- 13, (* equal contributors) (Featured Cover Article)
  • Huang X, Ding L, Bennewith KL, Tong RT, Welford SM, Ang KK, Story M, Le QT, & Giaccia
    AJ. Hypoxia inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Molec Cell, 2009; 35(6): 856-67, 2009. (Comments at Molecular Cell, 35:737, 2009; & Nat Rev Cancer 9:769, 2009)
  • Huang X, Gollin SM, Raja S, & Godfrey TE. High resolution mapping of the 11q13
    amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells. Proc Nat Acad Sci USA, 2002; 99(17):11369-74.
  • Huang X, Le QT, Giaccia AJ. MiR-210 – micromanager of the hypoxia pathway. Trends in
    Molecular Medicine 2010; 16(5): 230-237,
  • Suryawanshi S*, Vlad AM*, Lin HM, Mantia-Smaldone G, , Laskey R, Lee M, Lin Y,
    Donnellan N, Klein-Patel M, Lee T, Mansuria S, Elishaev E, Budiu R, Edwards RP, Huang X. Plasma microRNAs as novel biomarkers for endometriosis and endometriosis-associated ovarian cancer. Clinical Cancer Research 2013; 19(5): 1213-1224. (* equal contributions)
  • Huang X, Zuo J. Emerging Roles of miR-210 and Other Noncoding RNAs in the Hypoxic
    Response. Acta Biochimica et Biophysica Sinica 2014; 46(3): 220-232.
  • Feng Y*, Zhang S*, Huang X. A robust TALENs system for highly efficient mammalian
    genome editing. Scientific Reports 2014, 4: 3632. (* equal contributions)

For additional publications, see: http://www.ncbi.nlm.nih.gov/sites/myncbi/1PeB7GGC9ruAu/bibliography/43322783/public/?sort=date&direction=ascending

 

Links