Assistant Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, Division of Gynecological Oncology, University of Pittsburgh
The main goals of the Huang laboratory are to: (1) Understand the role of tumor hypoxia in ovarian cancer initiation and progression, especially the function of the hypoxia-inducible microRNA, miR-210, during this process. (2) Identify genes critical for ovarian cancer transcoelomic metastasis. (3) Identify biomarkers for ovarian cancer early detection and prognosis.
Ho AS*, Huang X*, Cao H, Christman-Skieller C, Le QT, & Koong AC. Circulating miR-210
as a novel hypoxia marker in pancreatic cancer. Translational Oncology, 2010; 3(2): 109- 13, (* equal contributors) (Featured Cover Article)
Huang X, Ding L, Bennewith KL, Tong RT, Welford SM, Ang KK, Story M, Le QT, & Giaccia
AJ. Hypoxia inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Molec Cell, 2009; 35(6): 856-67, 2009. (Comments at Molecular Cell, 35:737, 2009; & Nat Rev Cancer 9:769, 2009)
Huang X, Gollin SM, Raja S, & Godfrey TE. High resolution mapping of the 11q13
amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells. Proc Nat Acad Sci USA, 2002; 99(17):11369-74.
Huang X, Le QT, Giaccia AJ. MiR-210 – micromanager of the hypoxia pathway. Trends in
Molecular Medicine 2010; 16(5): 230-237,
Suryawanshi S*, Vlad AM*, Lin HM, Mantia-Smaldone G, , Laskey R, Lee M, Lin Y,
Donnellan N, Klein-Patel M, Lee T, Mansuria S, Elishaev E, Budiu R, Edwards RP, Huang X. Plasma microRNAs as novel biomarkers for endometriosis and endometriosis-associated ovarian cancer. Clinical Cancer Research 2013; 19(5): 1213-1224. (* equal contributions)
Huang X, Zuo J. Emerging Roles of miR-210 and Other Noncoding RNAs in the Hypoxic
Response. Acta Biochimica et Biophysica Sinica 2014; 46(3): 220-232.
Feng Y*, Zhang S*, Huang X. A robust TALENs system for highly efficient mammalian
genome editing. Scientific Reports 2014, 4: 3632. (* equal contributions)