The Women’s Cancer Research Center at Magee-Womens Research Institute focuses on the areas of reproductive tract cancers and breast cancer.

The team interrogates fundamental processes that lead to carcinogenesis, focusing on the role of the immune system in tumor formation, particularly in ovarian cancer, with an emphasis on anti-cancer vaccine development. Basic studies also center on genetic and epigenomic pathways that contribute to cancer. A prime goal in the group’s translational research labs is the identification of biomarkers for cancer risk, severity, prognosis, and response to therapy. The group also focuses on large-scale clinical trials, performed as a part of the national Gynecologic Oncology Group consortium, conducting trials involving ovarian, cervical, endometrial, and vulvar cancers.

An important component of the Women’s Cancer Research Center research program examines the causes, prevention, and treatment of breast cancer, and assesses the psychosocial and behavioral impact of breast cancer on a woman’s quality of life.  Specifically, research focuses on resistance to endocrine treatment, genetic and epigenetic changes in breast cancer development and progression, breast cancer metastases, stem cells, and invasive lobular breast cancer.