Research Support

We are grateful for the philanthropic support that enables us to provide the most comprehensive menu of fertility preservation options to patients in Western Pennsylvania and beyond and also to develop the next generation of fertility preservation technologies.

 

Current Support

Sylvia Bernassoli Fund for Fertility Research

2013 and ongoing

http://www.mwrif.org/news_display/view/479

 

Completed Support

Department of Urology

2015-2016

Fertility Preservation Program

 

Department of OB/GYN & Reproductive Sciences/Magee-Womens Research Institute &
Foundation

2012-2014 Fertility Preservation Program

 

Michael and Julie McMullen

2012-2014

Fertility Preservation Research

http://www.mwrif.org/444/ovarian-cancer-survivor-julie-mcmullen

 

Richard King Mellon Foundation (PI:Orwig)

2011-2012

Preserving Fertility in Patients with Cancer and Immunological Conditions that Require Bone Marrow Transplants-Including Boys and Girls

 

Scaife Family Foundation Pilot Project Grant (PI: Orwig)

2009-2011

Processing and Cryopreservation of Ovarian Tissue
Magee-Womens Research Institute and Foundation matching funds (PI:Orwig)2

009-2011

Fertility Preservation Program

 

 

Research Findings

Selected Publications

  • Gassei K and Orwig KE. Experimental methods to preserve male fertility and treat male factor infertility. Fertil and Steril 2015; [Epub ahead of print].
  • Gassei K, Valli H, Orwig KE. Whole-mount immunohistochemistry to study spermatogonial stem cells and spermatogenic lineage development in mice, monkeys, and humans. Methods Mol Biol. 2014; 1210: 193–202.
  • Valli H, Sukhwani M, Dovey SL, Peters KA, Donohue JN, Chu T, Marshall GR, Orwig KE. FACS and MACS sorting strategies to isolate and enrich human spermatogonial stem cells. Fertil Steril 2014; 102: 566-580.
  • Valli H, Phillips BT, Shetty G, Byrne JA, Clark AT, Meistrich ML, Orwig KE. Germline stem cells: toward the regeneration of spermatogenesis. Fertil Steril 2014; 101:3-13.
  • Dovey SL, Valli H, Hermann BP, Sukhwani M, Donohue J, Castro CA, Chu T, Sanfilippo JS, Orwig KE. Eliminating malignant contamination from therapeutic human spermatogonial stem cells. Journal of Clinical Investigation 2013; 123: 1833-1843.
  • Hermann BP, Sukhwani M, Winkler F, Pascarella JN, Peters KA, Sheng Y, Valli H, Rodriguez M, Esselarab M, Dargo G, Peterson K, Masterson K, Ramsey C, Ward T, Lienesch M, Volk A, Cooper DK, Thomson AW, Kiss JE, Penedo MT, Schatten GP, Shoukhrat M and Orwig KE. Spermatogonial stem cell transplantation into Rhesus testes regenerates spermatogenesis producing functional sperm. Cell Stem Cell 2012; 11:715-26.

 

Our Studies

The following studies are currently enrolling patients at this time. Please call our dedicated fertility preservation phone line at (412)641-7475 to speak to a nurse and learn more about the options for preserving your fertility.

TESTICULAR TISSUE FREEZING STUDY
Principal Investigator Kyle Orwig, PhD
Participants must be
  • Males older than 1 year old with two testes
  • Have a newly diagnosed or recurrent disease that requires chemotherapy or radiation treatment and puts them at high risk for infertility
Description The Fertility Preservation Program in Pittsburgh is conducting an experimental research study for young patients facing chemotherapy or radiation therapies that can threaten fertility. For these young patients who are not yet producing mature sperm, the Fertility Preservation Program is approved to freeze testicular tissue that might be used in the future to restore fertility when experimental techniques emerge from the research pipeline.
Compensation The FPP program will cover the costs of surgery, tissue processing, tissue freezing, and the first year of frozen storage.
For more information Please call the Fertility Preservation Program’s dedicated phone line at 412-641-7475.
Other Related Studies Ovarian Tissue Freezing

Oocyte Freezing

Genetic Effects of Chemotherapy on Sperm

OVARIAN TISSUE FREEZING STUDY
Principal Investigator Peter Shaw, MD
Participants must be
  • Females age 1 to 40 with two ovaries
  • Have a newly diagnosed or recurrent disease that requires chemotherapy or radiation treatment and puts them at high risk for infertility
Description The Fertility Preservation Program in Pittsburgh is conducting an experimental research study for young patients facing chemotherapy or radiation therapies that can threaten fertility. For these young patients who are not yet producing mature eggs, the Fertility Preservation Program is approved to freeze ovarian tissue that might be used in the future to restore fertility when experimental techniques emerge from the research pipeline.
Compensation The FPP program will cover the costs of surgery, tissue processing, tissue freezing, and the first year of frozen storage.
For more information Please call the Fertility Preservation Program’s dedicated phone line at 412-641-7475.
Other Related Studies Testicular Tissue Freezing

Oocyte Freezing

Genetic Effects of Chemotherapy on Sperm

GENETIC EFFECTS OF CHEMOTHERAPY ON SPERM STUDY
Principal Investigator Kyle Orwig, PhD
Participants must be
  • Adult males ages 18 through 50
  • Scheduled to undergo treatment with chemotherapy for a medical indication
  • Participants must not have any prior chemotherapy or radiation treatments
  • Participants with oligospermia (very low sperm counts) or azospermia (absent sperm count) will be excluded
Description The Fertility Preservation Program in Pittsburgh is conducting an experimental research study for adult male patients facing chemotherapy treatment. For these patients, semen will be collected prior to chemotherapy and after initiating chemotherapy. The majority of the sample collected before chemotherapy will be reserved for your clinical use in the future.
Compensation Study participants who complete the study will receive $263. Your insurance provider will be charged for the costs of semen analysis and collection of the sample taken before chemotherapy as this is standard of care. You will be responsible for the cost of semen cryopreservation and storage. You will not be charged any fees associated with semen samples collected after chemotherapy as these are research only samples.
For more information Please call the Fertility Preservation Program’s dedicated phone line at 412-641-7475.
Other Related Studies Testicular Tissue Freezing

Ovarian Tissue Freezing

 

FERTILITY ASSESSMENT IN PATIENTS WITH KLINEFELTER SYNDROME STUDY
Principal Investigator Kyle Orwig, PhD

Selma Witchel, MD

Participants must be
  • Males between the ages of 12 and 25
  • Diagnosed with mosaic or non-mosaic Klinefelter’s Syndrome
  • Having bilaterally descended testes
Description The Fertility Preservation Program in Pittsburgh is conducting an experimental research study for adolescent and young adult male patients with Klinefelter Syndrome. Patients will be counselled on the impact of Klinefelter on their future fertility. Urine samples will be collected and endocrine data will be collected from the medical record. Participants will have the opportunity to also pursue a semen analysis, but this is not mandatory for study participation.
Compensation No direct payment will be made to the patient and/or his family for participating in this study. If a patient decides to pursue semen analysis as a result of the counselling he receives during study participation, the study will cover the cost for semen analysis at CFRE, as well as the first year of storage. A credit will be directly applied to the patient’s account.
For more information Please call the Fertility Preservation Program’s dedicated phone line at 412-641-7475 or email us at fertilitypreservation@upmc.edu.
Other Related Studies N/A