Research in Brief
Studying the tumor microenvironment to identify vulnerabilities of cancers.
Selected Publications
Mukherjee A, Bezwada D, Greco F, Zandbergen M, Shen T, Chiang CY, Tasdemir M,Fahrmann J, Grapov D, La Frano MR, Vu HS, Faubert B, Newman JW, McDonnell LA,Nezi L, Fiehn O, DeBerardinis RJ, Lengyel E. Adipocytes reprogramcancer cell metabolism by diverting glucose towards glycerol-3-phosphate thereby promotingmetastasis. Nat Metab. 2023Aug 31.
Mukherjee A, Bilecz J. Agnes, LengyelE. Adipocytes in the tumor Microenvironment. Cancer Metastasis Rev. 2022 Sep; 41(3):575-587.
Mukherjee A, Chiang CY, Daifotis HA, Nieman KM, Fahrmann JF, Lastra RR, Romero IL,Fiehn O, Lengyel E. Adipocyte-Induced FABP4 Expression in Ovarian Cancer Cells Promotes Metastasis and Mediates Carboplatin Resistance. CancerRes. 2020 Apr 15; 80(8):1748-1761.
Curtis M, Kenny HA, Ashcroft B, Mukherjee A, JohnsonA, Zhang Y, Helou Y, Batlle R, Liu X, GutierrezN, Gao X, Yamada SD, Lastra R, Montag A, AhsanN, Locasale JW, Salomon AR, Nebreda AR, Lengyel E. Fibroblasts Mobilize Tumor Cell Glycogen to Promote Proliferation and Metastasis. CellMetab. 2018 Aug 28. pii: S1550-4131(18)30508-4.
Mukherjee A, Kenny HA, Lengyel E. Unsaturated Fatty Acids Maintain Cancer Cell Stemness. Cell Stem Cell. 2017 Mar 2; 20(3):291-292.