Pregnancy & Newborn Medicine
DID YOU KNOW THOSE FIRST NINE MONTHS CAN ACTUALLY AFFECT OUR ENTIRE LIVES?
We study maternal health and fetal and placental development to ensure healthy mothers and babies, of course. But examining the first nine months can also help us predict diseases and conditions that may occur over a lifetime. And even change their course.
SPOTLIGHT ON: PRETERM BIRTH
Premature birth is the #1 killer of babies, and in 40% of the cases, the cause is unknown.
Preterm births put babies at risk for serious, life-long health problems, including:
- Chronic lung disease
- Learning disabilities
- Adult diabetes and heart disease
One in ten premature births is related to placental abruption.
Placental abruption occurs when the placenta separates from the uterus during pregnancy and can mean severe consequences for the baby, including:
- Cerebral palsy
- Learning disabilities
- Premature labor
- Higher risk of heart disease, obesity, and type 2 diabetes
Women who have complications during pregnancy are at greater risk of heart disease.
Heart disease is the number-one killer of women, killing more women than all cancers combined. Women who have complications during pregnancy are more likely to develop cardiovascular disease a decade and more after giving birth.
WHAT MAGEE SCIENTISTS ARE DOING
- We are working to advance scientific knowledge about premature births, translating our discoveries into improved health care for mothers and their babies.
- We are investigating the roots of preterm birth, especially within families with a history of premature delivery.
- We are identifying causes of placental dysfunction that may contribute to preterm birth, other adverse pregnancy outcomes, and lifelong health risks.
- We are studying what the placenta can teach us about the mother’s long-term cardiovascular health.
- We are collaborating with Magee Neonatal ICU physicians to develop better treatment and programs for preterm babies and their families.
Clinical Research & Trials
For over two decades, we have dedicated our clinical research studies and clinical trials to improving the health care of women, men, and infants everywhere. Our research would not be possible without the generous participation of many study volunteers.Learn More
Dr. Yoel Sadovsky’s laboratory utilizes molecular and cellular approaches to decipher mechanisms underlying placental development, differentiation, and response to injury. Research in Dr. Sadovsky’s lab seeks to understand the complexities of the placenta in order to understand the health of a pregnancy, and health across the lifespan.
Dr. Hyagriv Simhan’s research focuses on understanding why preterm birth occurs, including investigating how maternal nutritional status influences the immune system, exploring the genetics related to preterm birth, and investigating the biology and effectiveness of progesterone in preventing preterm birth from occurring. In addition, his research examines the various roles stress, inflammation, and the physical and social environment play in pregnancy outcomes.