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- Jacob C. Larkin, MD
Jacob C. Larkin, MD
Associate Professor & Vice Chair for Quality, Department of Obstetrics, Gynecology & Reproductive Sciences, University of Pittsburgh School of Medicine; Division of Maternal–Fetal Medicine, UPMC Magee‑Womens Hospital
Work in our lab focuses on the mechanistic and clinical determinants of fetal growth abnormalities, particularly fetal growth restriction. We are actively engaged in uncovering the underlying relationship between perinatal mortality and fetal growth through the analysis of large data sets. This analysis will facilitate the determination of diagnostic criteria for fetal growth restriction that will reflect relevant clinical risk thresholds.
Jacob C. Larkin, MD
Research in Brief
Dr. Larkin studies why some babies grow too slowly in the womb, a condition that can lead to serious health risks. His team looks at placenta biology and patient data to improve how we detect and manage fetal growth problems—from better tests to timely care—to ensure safer outcomes for moms and babies.
Current Projects
- Analyzing large clinical datasets to refine diagnostic criteria and outcomes of fetal growth restriction.
- QI initiatives to improve delivery of inpatient obstetric care.
Selected Publications
- Larkin JC, Speer PD, Simhan HN. “A customized standard of large size for gestational age to predict intrapartum morbidity.” Am J Obstet Gynecol. 2011;204(6):499.e1–10
- Larkin JC, Hill LM, Speer PD, Simhan HN. “Risk of morbid perinatal outcomes in small‑for‑gestational‑age pregnancies.” Obstet Gynecol. 2012;119(1):21–27
- Shi XH, Larkin JC, Chen B, Sadovsky Y. “N‑myc downstream-regulated gene 1 in human trophoblasts.” PLoS One. 2013;8(9)
- Larkin JC, Sears SB, Sadovsky Y. “Ligand‑activated LXR influence on primary human trophoblasts.” Placenta. 2014;35(11):919–24
For additional publications, visit Pubmed.