Maisa N. Feghali, MD, MS

Assistant Professor, Department of Obstetrics, Gynecology & Reproductive Sciences, Division of Maternal Fetal Medicine, Magee-Womens Hospital of UPMC

Research

Description:

Dr. Feghali aims to transform diabetes care during pregnancy through the use of individualized treatment strategies. Her early work identified differences in pregnancy outcomes in women with diabetes in pregnancy. She performed retrospective analyses and identified a spectrum of diabetes that lead to differences in pregnancy outcomes. She also examined predictors of treatment response and neonatal adverse outcomes in women with diabetes in pregnancy. This work demonstrated that diabetes in pregnancy is complex and highlighted the need for further research to determine a better treatment approach to improve maternal and fetal health. She has subsequently used data from the Obstetric-Fetal Pharmacology Research Collaborative studies to examine the response to different treatments for diabetes and the impact of obesity on treatment response. Her work has also looked at differences in the metabolic mechanisms of diabetes in pregnancy and laid the groundwork for a study evaluating individualized treatment for gestational diabetes mellitus, where treatment is matched to a woman’s mechanism of diabetes.

 

Selected publications:

  1. Feghali MN, Mattison DR. Clinical Therapeutics in Pregnancy.  J of Biomed Biotechnol. 2011; 2011:783528. doi: 10.1155/2011/783528. Epub 2011 Jul 6.  PMID: 21785566
  2. Feghali MN, Khoury JC, Shveiky D, Miodovnik M. Association of vaginal delivery efforts with retinal disease in women with type I diabetes. J Matern Fetal Neonatal Med. 2012 Jan;25(1):27-31. Doi: 10.3109/4767058.2012.626924. Epub 2011 Nov 1.  PMID 21957876
  3. Feghali MN, Khoury JC, Timofeev J, Shveiky D, Driggers RW, Miodovnik M. Asymmetric large for gestational age newborns in pregnancies complicated by diabetes mellitus: is maternal obesity a culprit? J Matern Fetal Neonatal Med. 2012 Jan;25(1):32-35. doi: 10.310914767058.2012.626925. PMID: 21957900.
  4. Scifres CM, Feghali MN, Althouse AD, Caritis SN, Catov JM. Effect of excess gestational weight gain on pregnancy outcomes in women with type 1 diabetes. Obstet Gynecol. 2014 Jun;123(6):1295-302. PubMed PMID: 24807331.
  5. Feghali M, Timofeev J, Huang CC, Driggers R, Miodovnik M, Landy HJ, Umans JG.Preterm induction of labor: predictors of vaginal delivery and labor curves. Am J Obstet Gynecol. 2015 Jan;212(1):91.e1-7. doi: 10.1016/j.ajog.2014.07.035. Epub 2014 Jul 25. PubMed PMID: 25068566.
  6. Feghali M, Venkataramanan R, Caritis S.Prevention of preterm delivery with 17-hydroxyprogesterone caproate: pharmacologic considerations. Semin Perinatol. 2014 Dec;38(8):516-22. doi: 10.1053/j.semperi.2014.08.013. Epub 2014 Sep 23. PubMed PMID: 25256193.
  7. Scifres CM, Feghali MN, Althouse AD, Caritis SN, Catov JM. Adverse Outcomes and Potential Targets for Intervention in Gestational Diabetes and Obesity. Obstet Gynecol.2015 Aug;126(2):316-25. PubMed PMID: 26241421.
  8. Scifres CM, Feghali M, Dumont T, Althouse AD, Speer P, Caritis SN, Catov JM. Large-for-gestational-age ultrasound diagnosis and risk for cesarean delivery in women with gestational diabetes mellitus. Obstet Gynecol. 2015 Nov;126(5):978-86. PubMed PMID: 26444129.
  9. Feghali M, Venkataramanan R, Caritis S. Pharmacokinetics of Drugs in Pregnancy. Semin Perinatol. 2015 Nov;39(7):512-9. PubMed PMID: 26452316.
  10. Feghali MN, Caritis SN, Catov JM, Scifres CM. Timing of delivery and pregnancy outcomes in women with gestational diabetes. Am J Obstet Gynecol. Epub 2016 March 11.

For additional publications, see: https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/43826406/?sort=date&direction=ascending

 

Clinical trials:

Metabolis Analysis for Treatment Choice in Gestational Diabetes Mellitus (MATCh-GDM)
https://clinicaltrials.gov/ct2/show/NCT03029702?term=MATCh-GDM&rank=1