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William Walker, PhD
Associate Professor of Obstetrics, Gynecology and Reproductive Sciences
I am studying the complex processes required for male fertility, and I am working to identify novel approaches to regulate male fertility by determining how testosterone maintains sperm production.
William Walker, PhD
Research in Brief
Dr. Walker studies the hormones and cellular signals that regulate sperm production in men. His work aims to improve treatments for male infertility and develop safe, effective male contraceptives by understanding how hormones like testosterone support the cells that nourish sperm.
Current Projects
- Investigating the role of testosterone signaling pathways in Sertoli cells during spermatogenesis.
- Evaluating novel male contraceptive drugs using mouse models.
- Studying spermatogonial stem cell maintenance and differentiation.
Selected Publications
- Cooke, P and Walker WH. Male Fertility Requires Classical and Non-classical Androgen Signaling. Cell Reports. 2021;36:109557.
- Walker WH. Testosterone signaling and spermatogenesis. Steroids. 2020;161:108677.
- Aliberti, P, Ramaswamy, S, Sethi, R, Belgorosky, A, Chandran UR, Plant TM and Walker, WH. Gonadotropin Stimulation of the Juvenile Monkey (Macaca mulatta) for 48 h Results in Up-regulation of Testis miRNAs Expressed From the DLK1-DIO3 Imprinted Locus, a Known Regulator of Pluripotency and Cell Differentiation. Molecular Human Reproduction, 2019. Volume 25, Issue 3, Pages 124–136. doi: 10.1093/molehr/gay054. PMID: 30590698.
For additional publications, click here.