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- Hyagriv Simhan, MD, MS
Hyagriv Simhan, MD, MS
Professor, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine; Executive Vice Chair, Obstetrical Services, University of Pittsburgh School of Medicine; Director, Clinical Innovation for the Women’s Health Service Line, UPMC
We are working to advance scientific knowledge about how to make pregnancy safer for women and babies, translating our discoveries into improved health care for mothers and their babies.
Hyagriv Simhan, MD, MS
Research in Brief
Dr. Simhan's research focuses on understanding the causes of preterm birth, including the role of infections, inflammation, and genetics. By studying these factors, he aims to develop better ways to care for mothers and babies, reducing the risks associated with premature births.
Current Projects
- Investigating the genetic and environmental factors contributing to preterm birth.
- Conduct clinical trials of interventions to improve outcomes for pregnant and postpartum women
- Developing innovative clinical practices to improve women’s health care.
- Leading the Hatch program to promote clinical innovation in women's health.
Selected Publications
- Simhan HN, Ryckman KK, Williams SM, Krohn MA. Genetic regulation of cervical antiinflammatory cytokine concentrations during pregnancy. Am J Obstet Gynecol.
2008;199:163.e1-163.e11. - Simhan HN, Krohn MA. Am J Obstet Gynecol. First-trimester cervical inflammatory milieu and subsequent early preterm birth. 2009;200:377.e1-4.
- Bodnar LM, Krohn MA, Simhan HN. Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J Nutr. 2009;139(6):1157-61.
- Kalan AM, Simhan HN. Mid-trimester cervical inflammatory milieu and sonographic cervical length. Am J Obstet Gynecol. 2010;203:126.e1-5.
- Bodnar LM, Himes KP, Venkataramanan R, Chen JY, Evans RW, Meyer JL, Simhan HN. Maternal serum folate species in early pregnancy and risk of preterm birth. Am J Clin Nutr. 2010;92:864-71.
- Gosman GG, King WC, Schrope B, Steffen KJ, Strain GW, Courcoulas AP, Flum DR, Pender JR, Simhan HN. Reproductive health of women electing bariatric surgery. Fertil Steril 2010;94:1426-31.
- Simhan HN, Bodnar LM, Kim KH. Lower genital tract inflammatory milieu and the risk of subsequent preterm birth: an exploratory factor analysis. Paediatr Perinat Epidemiol 2011;25:277-82.
- Simhan HN, Himes KP, Venkataramanan R, Bodnar LM. Maternal serum folate species in early pregnancy and lower genital tract inflammatory milieu. Am J Obstet Gynecol 2011;205:61.e1-7.
- Ramaeker DM, Simhan HN. Sonographic cervical length, vaginal bleeding, and the risk of preterm birth. Am J Obstet Gynecol 2012;206:224.e1-4.
- Facco FL, Simhan HN. Short ultrasonographic cervical length in women with low-risk obstetric history. Obstet Gynecol 2013;122:858-62.
- Hutcheon JA, Platt RW, Abrams B, Himes KP, Simhan HN, Bodnar LM. A weight-gain-for-gestational-age z score chart for the assessment of maternal weight gain in pregnancy. Am J Clin Nutr 2013;97:1062-7.
- Gernand AD, Bodnar LM, Klebanoff MA, Parks WT, Simhan HN. Maternal serum 25-hydroxyvitamin D and placental vascular pathology in a multicenter US cohort. Am J Clin Nutr 2013;98:383-8.
- Moroz LA, Simhan HN. Rate of sonographic cervical shortening and biologic pathways of spontaneous preterm birth. Am J Obstet Gynecol 2014;210:555.e1-5.
- Scifres CM, Catov JM, Simhan HN. The impact of maternal obesity and gestational weight gain on early and mid-pregnancy lipid profiles. Obesity (Silver Spring) 2014;22:932-8.
- Tomedi LE, Simhan HN, Chang CC, McTigue KM, Bodnar LM. Gestational weight gain, early pregnancy maternal adiposity distribution, and maternal hyperglycemia. Matern Child Health J 2014;18:1265-70.
- Bodnar LM, Klebanoff MA, Gernand AD, Platt RW, Parks WT, Catov JM, Simhan HN. Maternal vitamin D status and spontaneous preterm birth by placental histology in the US Collaborative Perinatal Project. Am J Epidemiol 2014;179:168-76.
- Bodnar LM, Platt RW, Simhan HN. Early-pregnancy vitamin D deficiency and risk of preterm birth subtypes. Obstet Gynecol 2015;125:439-47.
For additional publications, click here.