Hyagriv Simhan, MD, MS
Professor, Department of Obstetrics, Gynecology and Reproductive Sciences, Executive Vice Chair of Obstetrical Services, University of Pittsburgh School of Medicine, Director of Clinical Innovation for the Women’s Health Service Line, UPMC.
Research in Brief
Dr. Hyagriv Simhan completed his undergraduate studies and medical school at Boston University. Following completion of his internship and residency in Obstetrics & Gynecology at the University of Pennsylvania, Dr. Simhan completed fellowship training in Maternal-Fetal Medicine and Reproductive Infectious Diseases and Immunology at the University of Pittsburgh.
Dr. Simhan is a maternal-fetal medicine physician, experienced perinatal researcher, and leader in obstetrical care clinical innovation, quality, and safety. He is experienced in clinical and translational research, with a focus on infection/inflammation, and gene-environment interactions in preterm birth. He was a member of the IOM Committee on “Preterm Birth: Causes, Consequences, and Prevention” and a co-author of the Committee’s report. He has led single-center human subjects and translational projects in this arena and has participated collaboratively in protocol development, project design, enrollment, analysis, and publication of multicenter studies on the genetics of preterm birth.
Since 2002, he has led a clinical and translational research operation at UPMC Magee-Womens Hospital and MWRI that has recruited and retained thousands of pregnant subjects, collecting high-quality data, processed and assayed biological samples, and successfully conducted detailed follow-up. His ongoing work has been instrumental in deepening knowledge regarding the developmental origins of offspring phenotypes, including the biology of aging and neurocognitive development.
Dr. Simhan is the founding director of the Hatch program in UPMC’s Women’s Health Service Line. Hatch is designed to champion clinical innovation in technology, operations, and payment strategies to advance health across the continuum of care.
Hatch aims to accelerate advances in virtual care, population health, and patient engagement by coordinating, integrating, and effectively advancing progress for inpatients, outpatients, and the Pittsburgh community using the full capacity of UPMC.
- Simhan HN, Ryckman KK, Williams SM, Krohn MA. Genetic regulation of cervical antiinflammatory cytokine concentrations during pregnancy. Am J Obstet Gynecol.
- Simhan HN, Krohn MA. Am J Obstet Gynecol. First-trimester cervical inflammatory milieu and subsequent early preterm birth. 2009;200:377.e1-4.
- Bodnar LM, Krohn MA, Simhan HN. Maternal vitamin D deficiency is associated with bacterial vaginosis in the first trimester of pregnancy. J Nutr. 2009;139(6):1157-61.
- Kalan AM, Simhan HN. Mid-trimester cervical inflammatory milieu and sonographic cervical length. Am J Obstet Gynecol. 2010;203:126.e1-5.
- Bodnar LM, Himes KP, Venkataramanan R, Chen JY, Evans RW, Meyer JL, Simhan HN. Maternal serum folate species in early pregnancy and risk of preterm birth. Am J Clin Nutr. 2010;92:864-71.
- Gosman GG, King WC, Schrope B, Steffen KJ, Strain GW, Courcoulas AP, Flum DR, Pender JR, Simhan HN. Reproductive health of women electing bariatric surgery. Fertil Steril 2010;94:1426-31.
- Simhan HN, Bodnar LM, Kim KH. Lower genital tract inflammatory milieu and the risk of subsequent preterm birth: an exploratory factor analysis. Paediatr Perinat Epidemiol 2011;25:277-82.
- Simhan HN, Himes KP, Venkataramanan R, Bodnar LM. Maternal serum folate species in early pregnancy and lower genital tract inflammatory milieu. Am J Obstet Gynecol 2011;205:61.e1-7.
- Ramaeker DM, Simhan HN. Sonographic cervical length, vaginal bleeding, and the risk of preterm birth. Am J Obstet Gynecol 2012;206:224.e1-4.
- Facco FL, Simhan HN. Short ultrasonographic cervical length in women with low-risk obstetric history. Obstet Gynecol 2013;122:858-62.
- Hutcheon JA, Platt RW, Abrams B, Himes KP, Simhan HN, Bodnar LM. A weight-gain-for-gestational-age z score chart for the assessment of maternal weight gain in pregnancy. Am J Clin Nutr 2013;97:1062-7.
- Gernand AD, Bodnar LM, Klebanoff MA, Parks WT, Simhan HN. Maternal serum 25-hydroxyvitamin D and placental vascular pathology in a multicenter US cohort. Am J Clin Nutr 2013;98:383-8.
- Moroz LA, Simhan HN. Rate of sonographic cervical shortening and biologic pathways of spontaneous preterm birth. Am J Obstet Gynecol 2014;210:555.e1-5.
- Scifres CM, Catov JM, Simhan HN. The impact of maternal obesity and gestational weight gain on early and mid-pregnancy lipid profiles. Obesity (Silver Spring) 2014;22:932-8.
- Tomedi LE, Simhan HN, Chang CC, McTigue KM, Bodnar LM. Gestational weight gain, early pregnancy maternal adiposity distribution, and maternal hyperglycemia. Matern Child Health J 2014;18:1265-70.
- Bodnar LM, Klebanoff MA, Gernand AD, Platt RW, Parks WT, Catov JM, Simhan HN. Maternal vitamin D status and spontaneous preterm birth by placental histology in the US Collaborative Perinatal Project. Am J Epidemiol 2014;179:168-76.
- Bodnar LM, Platt RW, Simhan HN. Early-pregnancy vitamin D deficiency and risk of preterm birth subtypes. Obstet Gynecol 2015;125:439-47.
For additional publications, visit Pubmed.