MWRI Trials at UPMC Hamot
Steve N. Caritis Magee Obstetric Maternal & Infant (MOMI) Database and Biobank
Biospecimens are collected for banking and future use in research. The biobank stores biological specimen and health information (through medical records review) that are then used for future research. Specimens are not associated with participants’ names. Specimens collected:
- 1st, 2nd, 3rd Trimesters: Maternal blood and urine
- L&D: Maternal blood, maternal urine, placenta, cord, cord blood
- After delivery: Infant meconium (has not yet started)
DP3: Deep Phenotyping of Pregnancy Project
Observational study of pregnant women 18 and older enrolled in their first trimester. The purpose of this study is to construct a blueprint of a healthy pregnancy. Participants complete questionnaires, wear a Fitbit, use an air monitor in the home, collect microbiome sample and provide specimen samples at appointments/delivery. (blood, urine, hair samples, placenta, and meconium)
Follow this link for more information on the Deep Phenotyping of Pregnancy Project.
Mesh Biorepository Study: Insight into the Pathogenesis of Mesh Complications
A biorepository and database of mesh-related complications aiming to better understand symptoms of mesh complications, and to identify which women are at greatest risk of experiencing complications. Investigators are also attempting to determine the way tissues react to mesh placement and how the specific properties of each type of mesh impacts complication rates. Understanding the mechanisms that cause mesh complications will ideally allow these adverse outcomes to be prevented in the future. Specimens/information collected:
- Mesh and associated vaginal tissue that is removed as part of your procedure that would otherwise be discarded.
- A vaginal biopsy sample, blood, urine, and swab samples.
- Questionnaires and a detailed medical history.
SCOOP3: Longitudinal nature of postoperative cognitive dysfunction in older women undergoing pelvic organ prolapse surgery
Women greater than or equal to 70 years old undergoing pelvic organ prolapse surgery assessed for postoperative cognitive dysfunction using neuropsychological and task based cognitive assessments at 2 weeks, 3 months, and 12 months postoperatively.
MIRACLE of LIFE Study: Observational Study of Pregnant Women to Validate Biomarkers of Pregnancy Complications Risk
Pregnant women, 18-45 years old with a single pregnancy less than 22 weeks gestation will be asked to have a blood draw and complete a short survey at a one-time study visit, which can align with a regular prenatal appointment or be scheduled at their convenience. The study aim is to validate a blood test designed to predict pregnancy complications.
TAPER Trial: Techniques for Applying Estrogen for Prevention of Recurrent UTIs
The TAPER Trial is a randomized clinical trial comparing two different techniques of applying estrogen cream to the vagina in order to prevent urinary tract infections. Vaginal estrogen is the only nonantibiotic medication with a Grade A recommendation for preventing recurrent UTIs in older women.
EVERY MOM STUDY
The purpose of this voluntary research study is to examine the relationship between the previous experience of trauma (or lack thereof) and extracellular vesicles, potential biomarkers of stress in the bloodstream, in first-time expectant mothers. A biomarker is a biological molecule found in the body that may be a sign of a normal or abnormal process
REDUCTION
To explore the safety of a culture-directed UTI treatment strategy and preliminary secondary outcomes of assigned treatments in women with a history of recurrent urinary tract infections.
Be the First to Know
Get the latest research, news, events, and more delivered to your inbox.