MWRI Trials at UPMC Hamot
Steve N. Caritis Magee Obstetric Maternal & Infant (MOMI) Database and Biobank
Biospecimens are collected for banking and future use in research. The biobank stores biological specimen and health information (through medical records review) that are then used for future research. Specimens are not associated with participants’ names. Specimens collected:
- 1st, 2nd, 3rd Trimesters: Maternal blood and urine
- L&D: Maternal blood, maternal urine, placenta, cord, cord blood
- After delivery: Infant meconium (has not yet started)
SCOOP3: Longitudinal nature of postoperative cognitive dysfunction in older women undergoing pelvic organ prolapse surgery
Women greater than or equal to 70 years old undergoing pelvic organ prolapse surgery assessed for postoperative cognitive dysfunction using neuropsychological and task based cognitive assessments at 2 weeks, 3 months, and 12 months postoperatively.
TAPER Trial: Techniques for Applying Estrogen for Prevention of Recurrent UTIs
The TAPER Trial is a randomized clinical trial comparing two different techniques of applying estrogen cream to the vagina in order to prevent urinary tract infections. Vaginal estrogen is the only nonantibiotic medication with a Grade A recommendation for preventing recurrent UTIs in older women.
EVERY MOM STUDY
The purpose of this voluntary research study is to examine the relationship between the previous experience of trauma (or lack thereof) and extracellular vesicles, potential biomarkers of stress in the bloodstream, in first-time expectant mothers. A biomarker is a biological molecule found in the body that may be a sign of a normal or abnormal process
REDUCTION
To explore the safety of a culture-directed UTI treatment strategy and preliminary secondary outcomes of assigned treatments in women with a history of recurrent urinary tract infections.
Mindful Moms
To determine if an 8-week therapy group that teaches mindfulness skills and other techniques from cognitive behavioral therapy improves the ability to manage difficult emotions during pregnancy and the postpartum period’.
AMPLIFY
To better understand what food insecurity is like for pregnant individuals and develop a new survey for food insecurity during pregnancy.
Completed Trials
- HH4NM: Heart Health 4 New Moms
- MERIT: Impact of Level III Support Procedures on Normalization of Enlarged Genital Hiatus After Minimally Invasive Sacrocolpopexy
- Developing and Testing an Evidence-Based Toolkit for Nursing Home Care of Residents With Obesity
- Women’s Microbiome Study
- MUSA: Mixed Urinary Incontinence
- DP3: Deep Phenotyping of Pregnancy Project
- Miracle of Life Study: Observational Study of Pregnant Women to Validate Biomarkers of Pregnancy Complications Risk
- HABIT: Optimizing Health From Pregnancy Through One Year Postpartum. A Sequential Multiple Assignment Randomized Trial (SMART) of Perinatal Lifestyle Interventions
- Obesity: Home and Community-Based Services
- PIEB: Impact Study on the Effects of Programmed Intermittent Epidural Bolus (PIEB) Implementation on Maternal-Fetal Safety and Anesthesia Workforce Resources
- ASB Focus Groups: Exploration of the Asymptomatic Bacteriuria Knowledge Gap Through Online Crowdsourcing and Patient Stakeholder Perspectives
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